Voelcker Academy

Research Symposium 2012

 

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Jeffrey S. Childers

Primate Models of Aging

Jeffrey S. Childers

Mentor(s): Corinna N. Ross, PhD, Suzette D. Tardif, PhD

Using a small New World primate, the marmoset, for translational biomedical research offers us many advantages over using rodents and nonhuman primate models. The use of these primates is beneficial becauseā€¦

  1. Characterization of aging and functional decline in a short-lived primate will allow new opportunities to understand human aging, therapeutics, and disease.
  2. Relationships between health, aging, tissue function, and diseases are often not well modeled in rodents.
  3. Primates are more genetically related to humans than rodents are.
  4. Studies of health and physical decline in aging humans have focused upon:
    Body composition (fat & lean mass)
    Activity Patterns
    Inflammation
    Gait
    Muscle strength
    Appetite
    Social function
    Cognitive function

If marmosets are similar to humans, the Tardif lab predicts:
  Decreased lean mass with age- sarcopenia
  Increased inflammatory status with age