Voelcker Academy

Research Symposium 2012

 

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Paige Livingston Lopez

Basic Function of IGF-1 and microRNA-29b in Regulation of Neuronal Apoptosis

Paige Livingston Lopez

Mentor(s): Shushan Rana, B.S., Shane Sprague, M.S., Lauren Fletcher, M.S., Murat Digicaylioglu, M.D./Ph.D., David Jimenez, M.D., F.A.C.S

  • Approximately 795,000 individuals in the United States suffer a new or recurrent stroke annually
  • Conditions such as hypoxia and ischemia induce alterations in microRNA expression
    • microRNAs are short, noncoding RNAs which regulate gene expression by inhibiting translation of mRNA into proteins
  • Ischemic and hypoxic conditions are caused by obstruction of blood, restricting glucose and oxygen availability for cell metabolism
  • Insulin is a hormone secreted by the pancreas, enabling cells to absorb glucose from the blood
  • Insulin-Like Growth Factor-I (IGF-I) exerts neuroprotective effects by inhibiting neuronal apoptosis in animal models of stroke

However, the underlying mechanisms remain unclear.