Voelcker Academy

Research Symposium 2010

 

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Jacob Carmichael

Intracellular Copper Trafficking Responds to Artherogenic Inflammatory Signaling

Jacob Carmichael

Mentor: Dr. Zhenyu Qin

ATP7A is a Copper-transporting ATPase that acts as a copper efflux within the cell body. It is essential for human system development, including creation of vascular tissue and neurological function. Atherosclerosis is a chronic vascular inflammation. Anti-inflammatory regimens hold great promises to treat the atherosclerotic cardiovascular disease. A better understanding of inflammatory signaling will help us to develop novel therapies.