Voelcker Academy

Research Symposium 2009


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Aspen Meineke

A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization

Aspen Meineke

Mentor(s): Meilian Liu, Lijun Zhou, Aimin Xu, Karen S.L. Lam, Michael D. Wetzel, Ruihua Xiang , Jingjiang Zhang, Xiaoban Xin, Lily Q. Dong, and Feng Liu

  • Adiponectin is a hormone secreted from fat tissue and plays an important role in glucose metabolism
  • ¬†Adiponectin exists in 3 main forms in fat tissue and bloodstream:
    • low-molecular-mass (LMM)
    • hexamer (MMW)
    • high-molecular mass (HMM)
  • The plasma HMM form of adiponectin¬† is decreased in type 2 diabetic patents.
  • DsbA-L is a protein that interacts with adiponectin and regulates adiponectin HMM formation.
  • DsbA-L is found in adipose tissue and its expression is negatively correlated with obesity in mice and humans.